郭和昌 醫師

Ho-Chang Kuo

亞洲排名第一川崎症專家

川崎症、川崎病、川崎氏症、Kawasaki Disease, Kawasaki Syndrome

川崎症團隊為第一個榮獲國家級生策會SNQ國家品質標章的醫療特色團隊,且為全台灣第一個川崎症照護團隊榮獲國家級品質認證。

川崎症是種兒童特有的疾病,發生率最高的國家是日本,由日本人川崎富作首先發現,台灣更高居此症全球好發率中的第三位,但現今全亞洲排名第一的川崎症專家不在日本,是在台灣的高雄長庚兒童醫院的郭和昌醫師。郭醫師所帶領的川崎團隊發表川崎症相關國際級醫學論文數量超過80篇,總數居全台灣之冠。其中包含世界頂尖的《自然遺傳期刊Nature Genetics 2011及2012》、美國兒科醫學會(Journal of Pediatrics 2014)、美國風濕病醫學會(Arthritis and Rheumatology 2015)、美國心臟學會(Circulation Research 2015)及美國過敏氣喘學院(JACI 2016、2018)、歐洲過敏免疫學會(Allergy 2015)…等。編撰川崎症章節之英文教科書共三個章節(InTech、Nova、Springer出版)。自2014年起榮獲全球客觀醫學專家排名系統Expertscape評選為全亞洲排名第一之川崎症專家;所屬機構之長庚醫療體系更名列全球第五川崎症專家單位。團隊出版第一本川崎症專書,成立全國第一個”川崎症中心”,開辦全國第一個”川崎症門診”提供家長明確就醫方向,組織全國第一個川崎關懷推廣團體”中華川崎症關懷協會”推廣家長認識川崎症。於2013年代表全亞太地區獲美國過敏免疫學會(AAAAI)頒發傑出研究獎、科技部吳大猷先生紀念獎、行政院江宜樺院長親自頒發救國團青年獎章及馬英九總統招見、五座亞洲兒科醫學會傑出研究獎、四座台灣兒科醫學會獎、歐洲過敏免疫學會EAACI獎,獲遴選為美國過敏氣喘免疫學院(FAAAAI)國際級院士。獲日本三重大學(Mie University, Japan)、湖南省兒科醫學會及陝西省人民醫院邀請演講,並協助陝西省人民醫院成立全中國第一個川崎症診療中心。製作川崎症衛教單、川崎症護照宣導認識川崎症及自創五-五-五-五準則及1-2-3-4-5診斷口訣,成功為川崎症創造了零死亡率照護,優於全球治療成果,展顯超於國際級照護水準。

2016年發明川崎症分子診斷方式榮獲第13屆國家新創獎。


專長

川崎症、川崎病、川崎氏症、Kawasaki Disease, Kawasaki Syndrome


治療經驗

  1. 川崎症超過3000人次診治
  2. 零死亡率
  3. 高度治療成功率(> 90%)
  4. 幾乎近於零的冠狀動脈瘤產生率(<1%)


個人網站、部落格

川崎症專家-郭和昌醫師微信

川崎症官網: www.kawasaki-disease-taiwan.com

川崎症臉書Facebook group: https://www.facebook.com/groups/120542631316130/

川崎症部落格 (Kawasaki disease blog): http://blog.xuite.net/erickuo48/kawasakidisease

川崎病專家-郭和昌醫師微博: https://www.weibo.com/kawasakidisease

學歷

陽明大學醫院院醫學系學士

長庚大學醫學院臨床醫學研究所博士


經歷

高雄長庚紀念醫院川崎症中心主任 (since 2013)

高雄長庚紀念醫院兒童內科部教授 (since 2017)

長庚大學醫學院副教授 (since 2014)

博士班導師

碩士班導師

指導國外學者:中國*3,澳洲,美國*2


現任

高雄長庚紀念醫院川崎症中心主任

高雄長庚紀念醫院兒童內科部教授

長庚大學醫學院副教授

中華川崎症關懷協會創會會長

Editor of Plos One and other 10+ international peer review medical journals.

美國過敏氣喘免疫學院國際院士(FAAAAI)

  1. 首創川崎症診斷口訣1-2-3-4-5,協助診斷川崎症
  2. 研究川崎症快速診斷方法,協助正確診斷川崎症
  3. 川崎症甲基化研究,使川崎症治療更佳專一有效
  4. 網路服務無遠弗屆,超過100個國家及10,000,000人次,協助全球川崎症研究,著作川崎症專書,行銷所有華人地區,造福川崎症及眾多家長。

說明如下:

(1) 設立全亞洲第一個『川崎症門診』及『川崎症病房』

(2) 設立全亞洲第一個『川崎症中心』

(3) 設立全台灣第一個『中華川崎症關懷協會』

(4) 於高雄長庚紀念醫院兒童大樓7樓佈置『川崎走廊』,提供川崎症衛教資訊。

(5) 出版川崎症專書:『兒童發燒五天竟導致心臟病:不可不知的川崎症』及『孩子高燒要當心-別讓川崎症傷了寶貝的心』

(6) 截至2018年09月全球已累積川崎症衛教演講場次共358場(陝西省人民醫院、湖南省兒童醫院、湖南省人民醫院、榆林市兒童醫院、榆林市國際兒科醫學會、陝西省神木縣醫院)

(7) 川崎症官網:http://www.kawasaki-disease-taiwan.com/

(8) 臉書粉絲專業:『中華川崎症關懷協會Kawasaki disease Taiwan-郭和昌醫師 HoChang Kuo』

(9) 微博:『川崎病专家-郭和昌医师

(10) 冠狀動脈瘤形成(aneurysm)比例優於國際一流醫院 (<1%)

(11) 免疫球蛋白(IVIG、丙球)治療成功率高於國際一流醫院 (92%)

(12) 國際知名客觀專家排名系統Expertscape評定為"亞洲排名第一川崎症專家"

(13) 近十年SCI國際級論文發表高居全球第二 (僅次於加州大學聖地牙哥分校)

(14) 發明川崎症分子診斷方式

(15) 發明川崎症診斷口訣

出版書籍

共計編著專書4本、專章3章

1. 兒童發燒五天竟導致心臟病: 不可不知的川崎症 (Oct 2011 1st version, 郭和昌 醫師主編, 麗文文化事業股份有限公司出版, ISBN 13/9789577484451, SBN 10/957748445X, EAN/9789577484451)

2. Ho-Chang Kuo, Wei-Chiao Chang; " Chapter10: Cardiovascular lesions of Kawasaki disease: From genetic study to clinical management", Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans. ISBN 978-953-51-0679-1, Hard cover, 390 pages, Publisher: InTech, Published: July 18, 2012.

3. Chronic Inflammation: Causes, Treatment Options and Role in Disease. Editors: Wei-Chiao Chang and Wen-Chang Chang. Chapter 5. Chronic Inflammation of Kawasaki Disease. (Ying-Hsien Huang and Ho-Chang Kuo) pp. 77-96. ISBN: 978-1-62808-094-0. 

4. Chronic Inflammation: Causes, Treatment Options and Role in Disease. Editors: Wei-Chiao Chang and Wen-Chang Chang. Chapter 10. Chronic Inflammation of Biliary Atresia (Ho-Chang Kuo, Jiin-Haur Chuang and Ying-Hsien Huang) pp. 157-170. ISBN: 978-1-62808-094-0.

5. Compendium of Inflammatory Diseases, Editors: Michael Parnham, ISBN: 978-3-0348-0620-6. (Online) Title: Kawasaki Disease. DOI: 10.1007/978-3-0348-0620-6_96-1, Publisher: Springer Basel

6. 郭和昌醫師告訴你: 孩子高燒要當心, 別讓川崎症傷了寶貝的心臟,(作者: 郭和昌 出版社/貓頭鷹出版社/出版日期2013/11/05; ISBN 13/9789862621790)

7. 國際過敏免疫專家告訴你:小兒過敏指數這樣算、那樣治療與預防 (作者: 郭和昌 出版社: 貓頭鷹; 出版日:2014/4/17; ISBN:9789862622032)

8. 川崎症口袋寶貝書,郭和昌/主編;麗文文化事業股份有限公司  出版日期:2017/02/25 , ISBN  13/9789577489173。ISBN 10/9577489176;EAN/9789577489173

9.由中華川崎症關懷協會所製作之川崎寶寶Line貼圖40張,Copyright ©Kawasaki Disease Center, 2017/03 上架 (Kawasaki Disease Line stickers)


專利

中華民國專利(I580788):用於檢測川崎症的方法及套組 (榮獲第13屆國家新創獎)

  1. 2011 Pediatric Academic Societies and Asian Society for Pediatric Research (PAS/ASPR) Joint meeting, Denver, Colorado, USA. (ASPR bEST RESEARCH AWARD)
  2. The best research article of 2011 (Otsuka respiratory), The Chinese Society of Pediatric Allergy, Asthma and Immunology
  3. The 8th Congress of Asian Society for Pediatric Research (ASPR), Seoul, Korea. 2012.-Young Investigators Award (YIA). (CD40 gene polymorphism in Kawasaki disease)
  4. The 8th Congress of Asian Society for Pediatric Research (ASPR), Seoul, Korea. 2012.-Young Investigators Award (YIA). (ITPKC and CASP3 gene polymorphism in Kawasaki disease)
  5. The 8th Congress of Asian Society for Pediatric Research (ASPR), Seoul, Korea. 2012.-Young Investigators Award (YIA). (Hepcidin in Kawasaki disease).
  6. 2013 The National Science Council, Taiwan. (Ta-You Wu Memorial Award. 國科會吳大猷紀念獎)
  7. The best research article of 2012 (MSD), The Chinese Society of Pediatric Allergy, Asthma and Immunology.
  8. 2012台灣兒科醫學會-第七屆亞洲兒科研究學會與美國兒科學會聯合會優秀摘要獎
  9. 2012 Research award of Professor Wen-Chang Liu, The Chinese Society of Immunology.
  10. 2013 American Academy of Allergy Asthma and Immunology (AAAAI) International Young Investigator Award.
  11. 2013 China Youth Corps Youth Metal. (救國團青年獎章)
  12. 2013 Distinguished Alumni Award, Chang Gung University. (Chang Gung University was ranked near the top 400 place in the Shanghai Jiao Tong Academic Ranking of World Universities長庚大學傑出校友)
  13. The best research article of 2013 (MSD), The Chinese Society of Pediatric Allergy, Asthma and Immunology.
  14. 2013年中華民國免疫學會”沈水德翁文教基金會學術論文獎”
  15. 2013 SNQ國家生技獎-國家品質標章-川崎症團隊
  16. 高雄長庚醫院100年度”優良教學成效醫師”
  17. 2014 The 10th Congress of Asian Society for Pediatric Research (ASPR)/Pediatric Academic Societies (PAS), Vancouver, Canada. Best Research Award (ASPR)
  18. 高雄長庚醫院103年甄選優良教師
  19. 103年長庚大學優良教師(研究類)
  20. 103年長庚體系王永在董事長頒發金牌”研究傑出貢獻卓越” Chang Gung Memorial Hospital System chairman awarded the gold medal in the "outstanding contribution to research excellence."
  21. The best research article of 2015 (Otsuka respiratory), The Chinese Society of Pediatric Allergy, Asthma and Immunology(台灣兒童過敏氣喘免疫及風濕病醫學會:大塚呼吸優秀學術論文獎)
  22. 財團法人風濕病基金會台灣抗風濕病聯盟(104年度宋欽章先生紀念獎助金)
  23. 中華民國呼吸治療師公會全國聯合會第十二屆呼吸治療師節國際學術研討會論文”第一名”
  24. 長庚醫療財團法人104年度住院醫師優良論文獎全長庚體系第三名,指導作者
  25. 2015台灣兒科醫學會-第十一屆亞洲兒科研究學會與美國兒科學會聯合會優秀摘要獎
  26. The best research article of 2016 (MSD), The Chinese Society of Pediatric Allergy, Asthma and Immunology. (2016兒童過敏氣喘免疫及風濕病醫學會默沙東兒童過敏氣喘優秀學術論文獎)
  27. 第13屆國家新創獎
  28. 2016 SNQ國家生技獎-國家品質標章-川崎症團隊
  29. 衛生福利部- 104年及105年度兒科重難症醫療照護團隊獎勵方案-兒童心臟科之川崎症推廣及全面照護方案
  30. 科技部101-106年度補助大專校院獎勵特殊優秀人才獎勵(長庚大學)
  31. 2016 Asian Society for Pediatrics Research, Bangkok, Thailand, Best Research Award. (Dr. Li)
  32. Travel award, The 81st Annual Scientific Meeting of the Japanese Circulation Society (JCS) 2017. Kanazawa, Japan.
  33. Travel award, The 61st Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology (JCR), Fukuoka, Japan.
  34. The best research article of 2017 (Nestle), The Chinese Society of Pediatric Allergy, Asthma and Immunology(台灣兒童過敏氣喘免疫及風濕病醫學會:雀巢優秀學術論文獎)
  35. 106年度高雄長庚醫學研究獎"青年研究獎"
  36. The Asian Pacific Society of Respirology (APSR) Congress 2017, Sydney, Australia─Travel Award.
  37. 第18屆醫療品質獎主題類菁英組金獎+創意獎
  38. 2017台北國際發明暨技術交易展金獎
  39. 106年度高雄長庚研究成果臨床應用獎勵第一名
  40. 2017年高雄長庚醫院精實醫療專案第一名:川崎症精實醫療
  41. Outstanding reviewer of The Journal of Pediatrics (ranking 4.8% in Pediatrics, Top 10% of the world)
  42. 國立陽明大學第15屆傑出校友
  43. Travel award, The 82st Annual Scientific Meeting of the Japanese Circulation Society (JCS) 2018. Tokyo, Japan.
  44. 台灣兒童過敏氣喘免疫及風濕病醫學會:雀巢優秀學術論文獎

1. 深圳李X博

川崎症免疫球蛋白2次治療在深圳市兒童醫院,廣州及香港求診無效,經過我們治療冠狀動脈於一個月自6.8mm改善至2.65mm


2. 湖北董X哲

川崎症於湖北治療後冠狀動脈瘤8.0mm,經治療三個月回覆正常


3. 澳門潘X弦

川崎症復發,於澳門鏡湖醫院治療後冠狀動脈瘤無法改善,經治療後明顯改善


4. 雲南昆明高X棋

動脈瘤7.1mm

160篇SCI論文 (80篇川崎症論文)

  1. Children’s Fever that Procures Heart Disease: Things You Must Know about Kawasaki Disease (Oct 2011 1st version, edited by doctor Kuo Ho-chang, Published by Liwer Publisher, ISBN 13/9789577484451, SBN 10/957748445X, EAN/9789577484451)
  2. Ho-Chang Kuo, Wei-Chiao Chang; " Chapter10: Cardiovascular lesions of Kawasaki disease: From genetic study to clinical management",  Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans. ISBN 978-953-51-0679-1, Hard cover, 390 pages, Publisher: InTech, Published: July 18, 2012.
  3. Chronic Inflammation: Causes, Treatment Options and Role in Disease. Editors: Wei-Chiao Chang and Wen-Chang Chang. Chapter 5. Chronic Inflammation of Kawasaki Disease. (Ying-Hsien Huang and Ho-Chang Kuo) pp. 77-96. ISBN: 978-1-62808-094-0. 
  4. Chronic Inflammation: Causes, Treatment Options and Role in Disease. Editors: Wei-Chiao Chang and Wen-Chang Chang. Chapter 10. Chronic Inflammation of Biliary Atresia (Ho-Chang Kuo, Jiin-Haur Chuang and Ying-Hsien Huang) pp. 157-170. ISBN: 978-1-62808-094-0.
  5. Compendium of Inflammatory Diseases, Editors: Michael Parnham, ISBN: 978-3-0348-0620-6. (Online) Title: Kawasaki Disease. DOI: 10.1007/978-3-0348-0620-6_96-1, Publisher: Springer Basel
  6. Doctor Kuo Ho-chang’s Advice: Beware of Fever, Don’t Let Kawasaki Disease Harm Your Baby’s Heart,(Author: Kuo Ho-change Publisher/Owl Publishing House Co., LTD./Date of Publication: 2013/11/05; ISBN 13/9789862621790)
  7. International Specialists of Immunology and AllergyIndex Calculation, Treatment, and Prevention of Pediatric Allergy ((Author: Kuo Ho-change Publisher/Owl Publishing House Co., LTD./Date of Publication: 2014/4/17; ISBN:9789862622032)
  8. Kawasaki Disease Pocket Handbook,Kuo Ho-chang/Chief Editor;Liwer Publisher, Date of Publication:2017/02/25, ISBN 13/9789577489173。ISBN 10/9577489176;EAN/9789577489173 
  9. 40 pieces of Kawasaki Disease Line stickers developed and launched by Taiwan Kawasaki Disease Care Association,Copyright ©Kawasaki Disease Center, 2017/03 start selling (Kawasaki Disease Line stickers)

 

Patent:

  1. Taiwan Patent (I580788): the method and kit set for Kawasaki Disease detection (prized granted by the 13th National Innovation Award)

 

代表論文

  1. Yi-Ching Lee, Ho-Chang Kuo, Jeng-Sheng Chang, Luan-Yin Chang, Li-Min Huang, Ming-Ren Chen, Chi-Di Liang, Hsin Chi, Fu-Yuan Huang, Meng-Luen Lee, Yhu-Chering Huang, Betau Hwang, Nan-Chang Chiu, Kao-Pin Huang, Pi-Chang Lee, Li-Ching Chang, Yi-Min Liu, Ying-Ju Chen, Chien-Hsiun Chen, Taiwan Pediatric ID Alliance , Yuan-Tsong Chen, Fuu-Jen Tsai, Jer-Yuarn Wu. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nature Genetics 2012 Mar 25;44(5):522-5. (Co-1st author) (2016, SCI IF: 27.959, ranking 2/166, Q1 in GENETICS & HEREDITY),
  2. I-Chun Lin, Jau-Ling Suen, Shau-Ku Huang, Shun-Chen Huang, Hsin-Chun Huang, Ho-Chang Kuo, Chi-Chen Wei, Feng-Shen Wang, Hong-Ren Yu, Kuender D. Yang. Dectin-1/Syk signaling is involved in Lactobacillus casei cell wall extract-induced mouse model of Kawasaki disease. Immunobiology 2013 Feb;218(2):201-12. (2016, SCI IF:2.720, ranking: 87/150, Q3 in Immunology)
  3. Ying-Jui Lin, I-Chun Lin, Hong-Ren Yu, Hsuan-Chang Kuo, Kuender D. Yang, Wei-Chiao Chang, Chi-Di Liang, Shih-Feng Liu, Ho-Chang Kuo*. Tricuspid Regurgitation in Acute Phase of Kawasaki Disease Associated With Intensive Care Unit Admission. Pediatr Cardiol. 2013 Feb;34(2):250-5. (corresponding author*,2016, SCI IF: 1.688, ranking 89/126, Q3 in CARDIAC & CARDIOVASCULAR SYSYEM), 被引用5次。
  4. Yu-Wen Hsu, Hsu-Chen Chien, Chi-Cheng Liang, Kuender D. Yang, Wei-Pin Chang, Ho-Chang Kuo*, Wei-Chiao Chang. Stromal Interaction Molecule 1 Polymorphisms are Associated with Coronary Artery Dilation but not with Aneurysm Formation in Patients with Kawasaki Disease. Journal of Experimental and Clinical Medicine. (corresponding author*)
  5. Ho-Chang Kuo, Wei-Chiao Chang, Kuender D Yang, Hong-Ren Yu, Chih-Lu Wang, Shu-Chen Ho, Chun-Yuh Yang. Kawasaki disease and subsequent risk of allergic diseases: a population-based matched cohort study. BMC Pediatrics 2013 Mar 23;13:38. (2016, SCI IF:2.071, ranking 43/121,  Q2 in Pediatrics)
  6. Chiu-Ping Lee , Ying-Hsien Huang , Yu-Wen Hsu , Kuender D. Yang , Hsu-Chen Chien , Hong-Ren Yu , Ya-Ling Yang , Chih-Lu Wang , Wei-Chiao Chang, Ho-Chang Kuo*. TARC/CCL17 Gene Polymorphisms and Expression Associated with Susceptibility and the Formation of Coronary Artery Aneurysms in Kawasaki Disease. Pediatr Res. 2013 Nov;74(5):545-51. (2016, SCI IF:2.882, ranking 17/121, Q1 in Pediatrics) (corresponding author*)
  7. Ho-Chang Kuo, Yu-Wen Hsu, Chung-Min Wu, Shawn Hsiang-Yin Chen, Kuo-Sheng Hung, Wei-Pin Chang, Kuender D. Yang, Kai-Sheng Hsieh, Wei-Chiao Chen, Yoshihiro Onouchi, and Wei-Chiao Chang. A Replication Study for Association of ITPKC and CASP3 Two-locus analysis in IVIG unresponsiveness and coronary artery lesion in Kawasaki disease. PLoS One. 2013 Jul 24;8(7):e69685.(2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES)
  8. Deniz Yeter, Richard Deth, Ho-Chang Kuo*. Mercury promotes catecholamines which potentiate mercurial autoimmunity and arterial vasodilation: implications for ITPKC susceptibility in Kawasaki syndrome. Korean Circ J. 2013 Sep;43(9):581-591. (corresponding author*) (2016, SCI IF:1.252, ranking: 104/126, Q4 in MU CARDIAC & CARDIOVASCULAR SYSYEM)
  9. Wei-Pin Chang, Shyh-JongWu, Wei-Chiao Chang, and Ho-Chang Kuo*. Population-Based Study of the Association between Urbanization and Kawasaki Disease in Taiwan. TheScientificWorldJournal 2013, Article ID 169365. (2010, SCI IF:1.524, ranking: 13/59, Q1 in MULTIDISCIPLINARY SCIENCES), (corresponding author*)
  10. Mei-Chen Ou-Yang, Ho-Chang Kuo, I-Chun Lin, Jiunn-Ming Sheen, Fu-Chen Huang, Chih-Cheng Chen, Ying-Hsien Huang, Ying-Jui Lin, and Hong-Ren Yu. Plasma clusterin concentrations may predict resistance to intravenous immunoglobulin in patients with Kawasaki disease. TheScientific WorldJournal, 2013, Article ID 382523, (2010, SCI IF:1.524, ranking: 13/59, Q1 in MULTIDISCIPLINARY SCIENCES), (co-1st author*)
  11. Chia-Jung Chang, Ho-Chang Kuo, Jong-Keuk Lee, Chiea Chuen Khor, Li-Ching Chang, Yi-Min Liu, Ying-Ju Chen, Young Mi Hong, Gi Young Jang, Martin L. Hibberd, Taco Kuijpers, David Burgner, Michael Levin, Jane Burns, Sonia Davila, International Kawasaki Disease Genetics Consortium, Korean Kawasaki Disease Genetics Consortium, Taiwan Kawasaki Disease Genetics Consortium, Yuan-Tsong Chen, Chien-Hsiun Chen, Jer-Yuarn Wu & Yi-Ching Lee. Replication of GWAS identification of Kawasaki disease susceptibility genes and a functional study affirm a role for BLK in disease susceptibility. PLoS One. 2013 Aug 30;8(8):e72037. (2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES)
  12. Peng Yeong Woon, Wei Chiao Chang, Chi-Cheng Liang, Chun Hung Hsu, Sukhontip Klahan, Ying-Hsien Huang, Wei-Pin Chang and Ho-Chang Kuo.* Increased Risk of Atopic Dermatitis in Preschool Children with Kawasaki Disease: A Population-based Study in Taiwan. Evid Based Complement Alternat Med. 2013;2013:605123 (corresponding author*) (SCI) )
  13. Kuo HC, Hsu YW, Lo MH, Huang YH, Chien SC, Chang WC. Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease. PLoS One. 2014 Mar 12;9(3):e91118. (2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES)
  14. Ho-Chang Kuo, Chung-Min Wu, Wei-Pin Chang, Chun-Nan Kuo, Deniz Yeter, Chun-Yi Lin, Jei-Tsung Pai, Ying-Chen Chi, Chia-Hsien Lin, Liang-Jen Wang and Wei-Chiao Chang. Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan. Int. J. Environ. Res. Public Health 2014 11(4), 3705-3716. (2016, SCI IF:2.101, ranking: 101/229, Q2 in ENVIRONMENTAL SCIENCES)
  15. Wu TH, Kuo HC, Tain YL, Lin KM, Kuo HC, Chien SJ. Common carotid artery intima-media thickness is useful for diagnosis of the acute stage of Kawasaki disease. BMC Pediatr. 2014 Apr 10;14(1):98. (2016, SCI IF:2.071, ranking 43/121, Q2 in Pediatrics)
  16. Huang YH, Tain YL, Lee CP, Kuo HC*. Asymmetric and Symmetric Dimethylarginine Are Associated with Coronary Artery Lesions in Kawasaki Disease. J Pediatr. 2014 Aug;165(2):295-9.. (corresponding author*) (SCI IF:4.122, ranking4/124, Q1 in Pediatrics)
  17. Wan-Ning Tseng, Mao-Hung Lo, Kai-Sheng Hsieh, Wei-Chiao Chang, Ho-Chang Kuo*. IL-31 associated with coronary artery lesion formation in Kawasaki disease. PLoS One. 2014 Aug 14;9(8):e105195. PLoS One. 2013 Aug 30;8(8):e72037. (2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES)
  18. Ho-Chang Kuo, Ying-Hsien Huang, Shu-Chen Chien, Hong-Ren Yu, Kai-Sheng Hsieh, Yu-Wen Hsu, and Wei-Chiao Chang. Genetic variants of CD209 associated with Kawasaki disease susceptibility. PLoS One. 2014 Aug 22;9(8):e105236 (2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES)
  19. Sandi C Lin, Wan-Lin Tseng, Mindy Ming-Huey Guo and Ho-Chang Kuo*. Etanercept as Rescue Therapy for Refractory Kawasaki Disease. Austin J Pediatr. 2014;1(2): 1010. (corresponding author*)
  20. Kuo HC*, Chang JC, Kuo HC, Yu HR, Wang CL, Lee CP, Huang LT, Yang KD. Identification of an Association Between Genomic Hypomethylation of FCGR2A and Susceptibility to Kawasaki Disease and Intravenous Immunoglobulin Resistance by DNA Methylation Array. Arthritis Rheumatol. 2015 Mar;67(3):828-36. (2016, SCI IF:6.918, ranking: 3/30, Q1 in RHEUMATOLOGY)
  21. Mindy Ming-Huey Guo, Wan-Ning Tseng, Chia-Hung Ko, Hui-Mei Pan, Kai-Sheng Hsieh, Ho-Chang Kuo*. Th17- and Treg-related cytokine and mRNA expression are associated with acute and resolving Kawasaki disease. Allergy 2015 Mar;70(3):310-8. (2016, SCI IF:7.361, ranking: 20/150, Q1 in IMMUNOLOGY)
  22. Ko TM, Kuo HC, Chang JS, Chen SP, Liu YM, Chen HW, Tsai FJ, Lee YC, Chen CH, Wu JY, Chen YT. CXCL10/IP-10 is a Biomarker and Mediator for Kawasaki Disease. Circ Res. 2015 Feb 27;116(5):876-83. (co-1st author) (2016, SCI IF:13.965, ranking: 5/126, Q1 in IMM CARDIAC & CARDIOVASCULAR SYSTEMS)
  23. Kuo HC, Hsu YW, Wu MS, Woon PY, Wong HS, Tsai LJ, Lin RK, Klahan S, Hsieh KS, Chang WC. FCGR2A Promoter Methylation and Risks for Intravenous Immunoglobulin Treatment Responses in Kawasaki Disease. Mediators Inflamm. 2015;2015:564625. (2016, SCI IF:3.232, ranking: 94/189, Q2 in CELL BIOLOGY)
  24. Guo MM, Tseng WN, Ou CY, Hsu TY, Kuo HC*, Yang KD. Predictive factors of persistent infantile atopic dermatitis up to 6 years old in Taiwan: a prospective birth cohort study. Allergy. 2015 Nov;70(11):1477-84. (2016, SCI IF:7.361, ranking: 20/150, Q1 in IMMUNOLOGY) (corresponding author)
  25. Kuo HC, Chang WC, Wang LJ, Li SC, Chang WP. Association of Attention deficit hyperactivity disorder and Kawasaki disease: a nationwide population-based cohort study. Epidemiol Psychiatr Sci. 2015 Sep 22:1-8. (2016, SCI IF:4.246, ranking: 16/139, Q1 in PSYCHIATRY)
  26. Ho-Chang Kuo*, Jen-Chieh Chang, Mindy Ming-Huey Guo, Kai-Sheng Hsieh, Deniz Yeter, Sung-Chou Li, Kuender D. Yang. Gene-gene associations with the susceptibility of Kawasaki disease and coronary artery lesions. PLoS One. 2015 Nov 30;10(11):e0143056. (1st and correspondence author) (2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES)
  27. Kuo H-C, Lo M-H, Hsieh K-S, Guo MM-H, Huang Y-H. High-Dose Aspirin Is Associated with Anemia and Does Not Confer Benefit to Disease Outcomes in Kawasaki Disease. PLoS ONE 2015, 10(12): e0144603. (2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES)
  28. Yeter D, Portman MA, Aschner M, Farina M, Chan WC, Hsieh KS, Kuo HC.* Ethnic Kawasaki Disease Risk Associated with Blood Mercury and Cadmium in U.S. Children. Int J Environ Res Public Health. 2016 Jan 5;13(1). (SCI IF: 2.063, correspondence author) (2016, SCI IF:2.101, ranking: 101/229, Q2 in ENVIRONMENTAL SCIENCES)
  29. Tseng HC, Ho JC, Guo MM, Lo MH, Hsieh KS, Tsai WC, Kuo HC*, Lee CH. Bull's eye dermatoscopy pattern at bacillus Calmette-Guérin inoculation site correlates with systemic involvements in patients with Kawasaki disease. J Dermatol. 2016 Sep;43(9):1044-50. (SCI IF: 1.577, corresponding author) (2016, SCI IF:2.094, ranking: 26/63, Q2 in DERMATOLOGY)
  30. Kuo HC, Hsu YW, Wu MS, Chien SC, Liu SF, Chang WC. Intravenous immunoglobulin, pharmacogenomics, and Kawasaki disease. J Microbiol Immunol Infect. 2016 Feb;49(1):1-7. (invited review article) (2016, SCI IF:2.973, ranking:77/150, Q2 in IMMUNOLOGY),
  31. Interferon-gamma Genetic Polymorphism and Expression in Kawasaki Disease. Huang YH, Hsu YW, Lu HF, Wong HS, Yu HR, Kuo HC, Huang FC, Chang WC, Kuo HC*. Medicine (Baltimore). 2016 Apr;95(17):e3501. ( corresponding author). (2016, SCI IF:1.803, ranking:58/154, Q2 in MEDICINE,GENERAL & INTERAL)
  32.  Huang YH, Kuo HC, Huang FC, Yu HR, Hsieh KS, Yang YL, Sheen JM, Li SC, Kuo HC*. Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients. Int J Mol Sci. 2016 May 12;17(5). (corresponding author) (2016, SCI IF:3.226, ranking:116/286, Q2 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
  33.  Kuo HC, Li SC, Guo MM, Huang YH, Yu HR, Huang FC, Jiao F, Kuo HC, Andrade J, Chan WC. Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease.  PLoS One. 2016 May 12;11(5):e0154943. (2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES),
  34.  Ho-Chang Kuo, Kai-Sheng Hsieh, Mindy Ming-Huey Guo, Ken-Pen Weng, Luo-Ping Ger, Wen-Ching Chan, Sung-Chou Li. Next generation sequencing identifies miRNA-based biomarker panel for Kawasaki disease. Journal of Allergy and Clinical Immunology. 2016 Oct;138(4):1227-1230. (2016, SCI IF:13.081, ranking: 6/150, Q1 in IMMUNOLOGY)
  35.  Li SC, Chan WC, Huang YH, Guo MM, Yu HR, Huang FC, Kuo HC, Kuo HC*. Major methylation alterations on the CpG markers of inflammatory immune associated genes after IVIG treatment in Kawasaki disease.  BMC Med Genomics. 2016 Aug 12;9 Suppl 1:37. (SCI IF: 3.13) (corresponding author). (2016, SCI IF:2.848, ranking: 73/166, Q2 in GENETICS & HEREDITY),
  36. Kuo HC, Wang CL, Yang KD, Lo MH, Hsieh KS, Li SC, Huang YH. Plasma Prostaglandin E2 Levels Correlated with the Prevention of Intravenous Immunoglobulin Resistance and Coronary Artery Lesions Formation via CD40L in Kawasaki Disease. PLoS One. 2016 Aug 15;11(8):e0161265. (2016, SCI IF:2.806, ranking: 15/64, Q1 in MULTIDISCIPLINARY SCIENCES)
  37. Hong-Ren Yu, Ying-Hsien Huang, Hsing-Chun Kuo, Fu-Chen Huang, Hsin-Chun Huang, Sung-Chou Li, Kai-Sheng Hsieh, Ho-Chang Kuo*. Distinct expressions of immunoglobulin signal related molecules between human Kawasaki disease and BALB/c mice treated with Lactobacillus asei cell wall extract. Int J Clin Exp Med 2016;9(10):19502-19511. (corresponding author) (2016, SCI IF:1.069, ranking: 104/128, Q4 in MEDICINE, RESEARCH & EXPERIMENTAL)
  38. Chang LS, Lo MH, Li SC, Yang MY, Hsieh KS, Kuo HC*. The effect of FcγRIIA and FcγRIIB on coronary artery lesion formation and intravenous immunoglobulin treatment responses in children with Kawasaki disease. Oncotarget. 2017 Jan 10;8(2):2044-2052.. (corresponding author) (2016, SCI IF:5.168, ranking: 48/189, Q2 in CELL BIOLOGY)
  39. Huang YH, Li SC, Huang LH, Chen PC, Lin YY, Lin CC, Kuo HC*. Identifying genetic hypomethylation and upregulation of toll-like receptors in Kawasaki disease. Oncotarget. 2017 Feb 14;8(7):11249-11258.  (SCI IF:5.008, corresponding author) (2016, SCI IF:5.168, ranking: 48/189, Q2 in CELL BIOLOGY)
  40. Huang FC, Kuo HC, Huang YH, Yu HR, Li SC, Kuo HC. Anti-inflammatory effect of resveratrol in human coronary arterial endothelial cells via induction of autophagy: implication for the treatment of Kawasaki disease. BMC Pharmacol Toxicol. 2017 Jan 9;18(1):3. (2016, SCI IF:2.288, ranking: 142/256, Q3 in PHARMACOOGY & PHARMACY)
  41. Huang YH, Kuo HC*. Anemia in Kawasaki Disease: Hepcidin as a Potential Biomarker. Int J Mol Sci. 2017 Apr 12;18(4). (SCI IF: 3.215, invited review, corresponding author) (2016, SCI IF:3.226, ranking:116/286, Q2 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
  42. Huang YH, Yang KD, Hsu YW, Lu HF, Wong HS, Yu HR, Kuo HC, Huang FC, Lo MH, Hsieh KS, Chen SF, Chang WC, Kuo HC*. Correlation of HAMP gene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease. Oncotarget. 2017 May 8;8(31):51859-51868. (corresponding author) (2016, SCI IF:5.168, ranking: 48/189, Q2 in CELL BIOLOGY)
  43. Kuo HC.* Preventing coronary artery lesions in Kawasaki disease. Biomed J. 2017 Jun;40(3):141-146. (invited review) (2016, SCI IF: 2.799, ranking: 111/190, Q3 in CELL BIOLOGY )
  44.  Chang LS, Hsu YW, Lu CC, Lo MH, Hsieh KS, Li SC, Chang WC, Kuo HC*. CYP2E1 Gene Polymorphisms Related to the Formation of Coronary Artery Lesions in Kawasaki Disease. Pediatr Infect Dis J. 2017 Nov;36(11):1039-1043. (2016, SCI IF: 2.486, ranking: 99/151, Q3 in IMMUNOLOGY)
  45. Liang-Jen Wang, Ho-Chang Kuo*. Cognitive Development After Kawasaki Disease- Clinical Study and Validation Using a Nationwide Population-Based Cohort. Circ J. 2017 Sep 9. doi: 10.1253/circj.CJ-17-0557. (2016, SCI IF: 3.544, ranking: 44/126, Q2 in CARDIAC & CARDIOVASCULAR SYSTEMS)
  46. Kuo HC, Wong HS, Chang WP, Chen BK, Wu MS, Yang KD, Hsieh KS, Hsu YW, Liu SF, Liu X, Chang WC. Prediction for Intravenous Immunoglobulin Resistance by Using Weighted Genetic Risk Score Identified From Genome-Wide Association Study in Kawasaki Disease. Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001625. (SCI IF: 4.7) (2016, SCI IF: 4.743, ranking: 29/126, Q1 in CARDIAC & CARDIOVASCULAR SYSTEMS)
  47. Kuo HC, Li SC, Huang LH, Huang YH. Epigenetic hypomethylation and upregulation of matrix metalloproteinase 9 in Kawasaki disease. Oncotarget. 2017 Jul 28;8(37):60875-60891. (2016, SCI IF: 5.168, ranking: 48/190, Q2 in CELL BIOLOGY)
  48. Kuo HC, Huang YH, Chung FH, Chen PC, Sung TC, Chen YW, Hsieh KS, Chen CS, Syu GD. Antibody Profiling of Kawasaki Disease Using Escherichia coli Proteome Microarrays. Mol Cell Proteomics. 2018 Mar;17(3):472-481. (SCI IF: 6.5) (2016, SCI IF: 6.54, ranking: 5/78, Q1 in BIOCHEMICAL RESEARCH METHODS)
  49. Huang YH, Kuo HC, Li SC, Cai XY, Liu SF, Kuo HC*. HAMP promoter hypomethylation and increased hepcidin levels as biomarkers for Kawasaki disease. J Mol Cell Cardiol. 2018 Mar 2;117:82-87. (SCI IF: 5.6) (corresponding author)
  50. Huang YH, Lo MH, Cai XY, Kuo HC*. Epigenetic hypomethylation and upregulation of NLRC4 and NLRP12 in Kawasaki disease. Oncotarget. 2018 Apr 10;9(27):18939-18948. (2016, SCI IF: 5.168, ranking: 48/190, Q2 in CELL BIOLOGY) (corresponding author)
  51.  Kuo HC, Lo CC, Lin PX, Kao CC, Huang YH, Lin BS. Wireless optical monitoring system identifies limb induration characteristics in patients with Kawasaki disease. J Allergy Clin Immunol. 2018 May 4. pii: S0091-6749(18)30631-6. (SCI IF: 13.258)
  52. Kuo HC*, Guo MM, Lo MH, Hsieh KS, Huang YH. Effectiveness of intravenous immunoglobulin alone and intravenous immunoglobulin combined with high-dose aspirin in the acute stage of Kawasaki disease: study protocol for a randomized controlled trial. BMC Pediatr. 2018 Jun 22;18(1):200. doi: 10.1186/s12887-018-1180-1.
  1. 2010 Apr. The 6th Congress of Asian Society for Pediatric Research and 51st Annual Meeting of Taiwan Pediatric Association, Taipei, Taiwan. (6th ASPR) 
  2. 2010 Apr. The 6th Congress of Asian Society for Pediatric Research and 51st Annual Meeting of Taiwan Pediatric Association, Taipei, Taiwan. (6th ASPR) 
  3. 2011 Apr. Pediatric Academic Societies and Asian Society for Pediatric Research (PAS/ASPR) Joint meeting, April 30 - May 3, 2011, in Denver, Colorado, USA. (7th ASPR) (ASPR BEST RESEARCH AWARD) 
  4. 2011 Nov. 7th World Congress of the World Society for Pediatric Infectious Diseases (WSPID), Nov 16-19, Melbourne, Australia. 
  5. 2012 Mar. American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting, Orlando, Florida, USA. 
  6. 2012 May. 8th Asian Society for Pediatric Research (ASPR), Seoul, Korea. (Young Investigators Award of 8th ASPR) 
  7. 2012 May. 8th Asian Society for Pediatric Research (ASPR), Seoul, Korea. (Young Investigators Award of 8th ASPR) 
  8. 2012 May. 8th Asian Society for Pediatric Research (ASPR), Seoul, Korea. (Young Investigators Award of 8th ASPR) 
  9. (9) 2012 June. European Academy of Allergy and Clinical Immunology (EAACI) Congress 2012, Geneva, Switzerland. 
  10. 2012 Oct. Asia Pacific Association of Pediatric Allergy, Respirology & Immunology 2012 (APAPARI 2012), Taipei, Taiwan. 
  11. 2013 9th Asian Society for Pediatric Research (ASPR), Kuching, Malaysia. 
  12. 2013 9th Asian Society for Pediatric Research (ASPR), Kuching, Malaysia. 
  13. 201210 APAPARI, Introduction of Juvenile idiopathic Arthritis, Taipei, Taiwan. 
  14. 20121103 Epigenetic and environment regulation of human disease. 
  15. 201311 Asia Pacific Congress of Allergy, Asthma and Clinical Immunology 2013 (APCAACI 2013)-Kawasaki disease. 
  16. 201312 台灣兒童心臟醫學會邀請專題演講-川崎症與過敏關連 
  17. 201411 The 51st Annual congress of Japanese Society of Pediatric Allergy and Clinical Immunology 
  18. 201411 Mie University Graduate School of Medicine (日本三重大學) 
  19. 201411湖南省醫學會

201209 報紙報導川崎症


2014 川崎症門診與川崎症關懷協會


2014 聯合報-亞洲排名第一川崎症專家


2018聯合新聞網(麻疹與川崎症「好像」 家長傻傻分不清好驚慌、麻疹、川崎症病徵相似易搞混)


2018蘋果日報(愛心女大生 繪貼圖救川崎兒)


2018中廣(四至六月川崎症好發期 幼童發燒五天要注意)